# 📐 L2 Spec — Correlative Light-Electron Microscopy (CLEM) Mismatch-Only Spec
**ID:** `L2-161-001` · **Status:** ⊙ Testnet (genesis catalog)
**Parents:** ⬆ Principle [`L1-161`](/artifact/l1/L1-161)
> **🎯 Tolerance (ε):** expression
> **⚖ Difficulty score:** 0.55 · **Delta tier:** 5
> **⛓ On-chain block:** 41554246
---
## 1. Domain Ω
**Type:** `range`
| Parameter | Unit | Range |
|---|---|---|
| H em | — | 1024 – 16384 |
| H lm | — | 512 – 8192 |
| W em | — | 1024 – 16384 |
| W lm | — | 512 – 8192 |
| Pixel em nm | nm | 0.5 – 10 |
| Scale mismatch | — | 0.0 – 0.5 |
| Registration error | — | 0.0 – 50 |
| Photobleaching pre em | — | 0.0 – 0.8 |
| Sample preparation artifact | — | 0.0 – 0.5 |
## 2. Tolerance (ε)
**Type:** `fn`
```
14.0 - 8.0 * scale_mismatch - 10.0 * sample_preparation_artifact - 0.2 * registration_error - 5.0 * photobleaching_pre_em
```
## 3. Difficulty
| Property | Value |
|---|---|
| Difficulty score | 0.55 |
| Delta tier | 5 |
## 4. Fingerprint
`ff8836e1d38756422e3977ea9aa0e37c4ddaf0d009def954eacfbe9f3fcfc54d`
## 5. On-chain Registration
- **Chain hash:** `0xf7ea87529eaf26a759063b0d6af8534756ec41c5afb6191efcce35d308419768`
- **Chain tx hash:** `0xabd35a9648e27bae3c88d7c4d18921c6bcf113d7172340da68e27f1a8d56644c`
- **Chain block:** `41554246`
---
## File Mapping
This bundle consists of: `L2-161-001.md`, `L2-161-001.json`.
| File | Role | How to regenerate |
|------|------|-------------------|
| `L2-161-001.md` | Source of truth — edit this | Human or LLM |
| `L2-161-001.json` | Structured metadata for the registry | LLM regenerates from the sections above |
**Prompt for your LLM after editing this Markdown:**
> Read the attached Markdown. Regenerate the sibling `.json` so every field matches.
> Preserve the schema documented in the rows above.
> Output each file in its own fenced code block tagged with the filename.
> Output only the JSON object.
_This Markdown was auto-synthesized from the catalog row for `L2-161-001`._
_Edit it, regenerate the JSON, and submit at [/submit](/submit) to claim the artifact._