{"artifact_id":"L1-513","layer":"L1","title":"Diabetic Retinopathy Grading from Fundus Imaging (PWDR)","domain":"Medical Imaging","sub_domain":"Retinal vasculature reconstruction with diabetic retinopathy ETDRS-grade categorical readout","physics_fingerprint":{"L_DAG":5.0,"title":"Diabetic Retinopathy Grading from Fundus Imaging (PWDR)","domain":"Medical Imaging","carrier":"photon","primitives":["L.fundus_acquisition","L.vessel_segmentation","L.lesion_segmentation","L.lesion_count_aggregation","L.etdrs_threshold_classifier","int.spatial"],"sub_domain":"Retinal vasculature reconstruction with diabetic retinopathy ETDRS-grade categorical readout","noise_model":"gaussian","problem_class":"linear_inverse_with_categorical_readout","solution_space":"1D_etdrs_severity_grade","difficulty_delta":3,"integration_axis":"spatial","sensing_mechanism":"fundus_color_photography_with_etdrs_grading"},"observable_profile":{"metric":"categorical_accuracy","regime":"Existence inherited from L1-049 fundus core. Uniqueness conditional on adequate image quality (no severe media opacity; pupil dilation enables peripheral retinal coverage); ETDRS-grade transition boundaries (the 4-2-1 rule) form measure-zero hypersurfaces in lesion-count space. Stability inherits L1-049's kappa_eff plus a small additive contribution from grader_inter_rater_variability_calibration. The threshold-continuity proof in discrete_readout demonstrates that ETDRS-grade is a well-defined function of lesion counts; misclassification probability scales linearly with lesion-count error away from the 4-2-1 hypersurface boundary. Joint Hadamard well-posedness for the coupled vasculature-reconstruction + ETDRS-threshold forward established by Wilkinson 2003 (foundational ICDR paper), Abramoff 2018 (FDA-cleared autonomous AI), Gulshan 2016 (deep-learning grading benchmarks), Ting 2017 (Asian-population validation), Bhaskaranand 2019 (real-world performance), and Solomon 2017 (DR screening guidelines).","secondary":"weighted_kappa_etdrs"},"size_tiers":{"center_spec":{"omega":{"H":2048,"W":2048,"SNR_dB":30,"image_quality":0.0,"media_opacity":0.0,"pixel_resolution_um":5.0,"pupil_dilation_state":1.0,"field_of_view_degrees":45,"peripheral_field_truncation":0.0,"grader_inter_rater_variability_calibration":0.0,"manual_vs_automated_lesion_segmentation_disagreement":0.0},"input_format":"color_fundus_image_with_grade_label","problem_class":"diabetic_retinopathy_etdrs_pwdr","forward_operator":"fundus_etdrs_pwdr_forward","epsilon_fn_center":"0.85_accuracy"},"omega_bounds":{"H":[512,8192],"W":[512,8192],"image_quality":[0.0,0.5],"media_opacity":[0.0,0.4],"field_of_view_degrees":[30,200]},"epsilon_bounds":{"categorical_accuracy":[0.5,0.99]},"allowed_problem_classes":["diabetic_retinopathy_etdrs_pwdr","diabetic_retinopathy_referrable_pwdr","diabetic_retinopathy_per_quadrant_pwdr"],"allowed_omega_dimensions":["H","W","field_of_view_degrees","pixel_resolution_um","SNR_dB","image_quality","pupil_dilation_state","media_opacity","peripheral_field_truncation","manual_vs_automated_lesion_segmentation_disagreement","grader_inter_rater_variability_calibration"],"allowed_forward_operators":["fundus_etdrs_pwdr_forward","fundus_icdr_pwdr_forward","fundus_etdrs_per_quadrant_forward"]},"hardness_fn":{"type":"epsilon_fn","delta":3,"kappa":100,"metric":"categorical_accuracy"},"initiator_dataset":[{"name":"primary","weight":1.0,"ipfs_cid":null,"license_hash":null}],"status":"testnet","staked_pwm":0.0,"chain_hash":"0x2cdbd05721a0533f7f9f3b0b29ab053ec0bc9e17cf9b7914ea0fc2e2975cdd35","chain_tx_hash":"0xd162e26a36f9adcd19383925254a415bde3896422ea4fb0a5d9474cb1b8f1458","chain_block":41553387}