{"artifact_id":"L1-412","layer":"L1","title":"Protein Folding Energy Landscape Inversion","domain":"Computational Biology","sub_domain":"Structural biology","physics_fingerprint":{"L_DAG":6.5,"title":"Protein Folding Energy Landscape Inversion","domain":"Computational Biology","carrier":"N/A","primitives":["N.pointwise","S.md.molecular_dynamics","O.rmsd.structure_comparison"],"sub_domain":"Structural biology","noise_model":"shot_poisson","problem_class":"nonlinear_inverse","solution_space":"3D_protein_structure","difficulty_delta":50,"integration_axis":"conformation_space","sensing_mechanism":"cryo_em_nmr_structure_determination"},"observable_profile":{"metric":"TM_score","regime":"Existence of the recovered 3D_protein_structure is guaranteed within the declared Omega bounds. Uniqueness holds on the measurement-supported subspace; out-of-support modes are controlled by declared priors. Stability is conditionally stable (kappa_eff ~= 10000000.0); conformational_heterogeneity dominates the stability cliff; the remaining mismatch parameters contribute higher-order bias terms. Shot poisson sets the irreducible data-fidelity floor.","secondary":"RMSD_Angstrom"},"size_tiers":{"center_spec":{"omega":{"N_residues":200,"map_SNR_dB":10,"N_conformations":1,"resolution_Angstrom":3.0},"input_format":"measurement_only","problem_class":"nonlinear_inverse","forward_operator":"cryo_em_nmr_structure_determination","epsilon_fn_center":"0.70 TM_score"},"omega_bounds":{"N_residues":[10,10000],"map_SNR_dB":[5,30],"N_conformations":[1,100],"resolution_Angstrom":[1.5,10.0]},"epsilon_bounds":{"TM_score":[0.1,1.0]},"allowed_problem_classes":["nonlinear_inverse"],"allowed_omega_dimensions":["N_residues","resolution_Angstrom","map_SNR_dB","N_conformations"],"allowed_forward_operators":["cryo_em_nmr_structure_determination"]},"hardness_fn":{"type":"epsilon_fn","delta":50,"kappa":10000000000.0,"metric":"TM_score"},"initiator_dataset":[{"name":"primary","weight":1.0,"ipfs_cid":null,"license_hash":null}],"status":"testnet","staked_pwm":0.0,"chain_hash":"0x8d1ac8ba34fb77a3f6168e7a8f27664ced1e4082d8d748c18eb95cf2f7b5e847","chain_tx_hash":"0xbd019dc9b103ba59d579a469649c3cf3bd2a5873356fed950380c083728ccc27","chain_block":41555219}