{"artifact_id":"L1-410","layer":"L1","title":"Tumor Growth Model Inversion","domain":"Computational Biology","sub_domain":"Cancer modeling","physics_fingerprint":{"L_DAG":2.5,"title":"Tumor Growth Model Inversion","domain":"Computational Biology","carrier":"N/A","primitives":["D.time","O.nls.tumor_fit","S.bootstrap.uncertainty_tumor"],"sub_domain":"Cancer modeling","noise_model":"lognormal","problem_class":"parameter_estimation","solution_space":"tumor_growth_parameter_vector","difficulty_delta":3,"integration_axis":"time","sensing_mechanism":"tumor_volume_imaging"},"observable_profile":{"metric":"volume_prediction_RMSE_percent","regime":"Existence of the recovered tumor_growth_parameter_vector is guaranteed within the declared Omega bounds. Uniqueness holds on the measurement-supported subspace; out-of-support modes are controlled by declared priors. Stability is conditionally stable (kappa_eff ~= 20); imaging_noise_percent dominates the stability cliff; the remaining mismatch parameters contribute higher-order bias terms. Lognormal sets the irreducible data-fidelity floor.","secondary":"time_to_progression_error_days"},"size_tiers":{"center_spec":{"omega":{"tumor_volume_mm3":1000,"N_imaging_timepoints":8,"imaging_noise_percent":10,"growth_rate_lambda_day":0.05},"input_format":"measurement_only","problem_class":"parameter_estimation","forward_operator":"tumor_volume_imaging","epsilon_fn_center":"15 volume_prediction_RMSE_percent"},"omega_bounds":{"tumor_volume_mm3":[10,100000],"N_imaging_timepoints":[3,50],"imaging_noise_percent":[2,50],"growth_rate_lambda_day":[0.001,0.5]},"epsilon_bounds":{"volume_prediction_RMSE_percent":[2,50]},"allowed_problem_classes":["parameter_estimation"],"allowed_omega_dimensions":["N_imaging_timepoints","tumor_volume_mm3","growth_rate_lambda_day","imaging_noise_percent"],"allowed_forward_operators":["tumor_volume_imaging"]},"hardness_fn":{"type":"epsilon_fn","delta":3,"kappa":500,"metric":"volume_prediction_RMSE_percent"},"initiator_dataset":[{"name":"primary","weight":1.0,"ipfs_cid":null,"license_hash":null}],"status":"testnet","staked_pwm":0.0,"chain_hash":"0x620e8df375d9196c6a63965210a58ca98b17a9b9ce5db9fec21c68b1431358f6","chain_tx_hash":"0x1778f33dfa3227c2f3e71c47c070508f97e6e04a38bcc50774df1a2470f4e149","chain_block":41555219}