{"artifact_id":"L1-408","layer":"L1","title":"Wright-Fisher Population Genetics","domain":"Computational Biology","sub_domain":"Population genetics","physics_fingerprint":{"L_DAG":3.0,"title":"Wright-Fisher Population Genetics","domain":"Computational Biology","carrier":"N/A","primitives":["N.pointwise","O.likelihood.allele_frequency","S.mcmc.popgen_posterior"],"sub_domain":"Population genetics","noise_model":"multinomial","problem_class":"parameter_estimation","solution_space":"population_genetic_parameter_vector","difficulty_delta":5,"integration_axis":"generations","sensing_mechanism":"allele_frequency_sequencing"},"observable_profile":{"metric":"Ne_estimation_RMSE_log","regime":"Existence of the recovered population_genetic_parameter_vector is guaranteed within the declared Omega bounds. Uniqueness holds on the measurement-supported subspace; out-of-support modes are controlled by declared priors. Stability is conditionally stable (kappa_eff ~= 100); population_structure_subdivision dominates the stability cliff; the remaining mismatch parameters contribute higher-order bias terms. Multinomial sets the irreducible data-fidelity floor.","secondary":"selection_coefficient_RMSE"},"size_tiers":{"center_spec":{"omega":{"s_selection":0.0,"Ne_effective":1000,"N_generations":20,"N_sampled_alleles":100},"input_format":"measurement_only","problem_class":"parameter_estimation","forward_operator":"allele_frequency_sequencing","epsilon_fn_center":"0.3 Ne_estimation_RMSE_log"},"omega_bounds":{"s_selection":[-0.1,0.1],"Ne_effective":[10,100000],"N_generations":[5,100],"N_sampled_alleles":[10,1000]},"epsilon_bounds":{"Ne_estimation_RMSE_log":[0.05,1.0]},"allowed_problem_classes":["parameter_estimation"],"allowed_omega_dimensions":["Ne_effective","N_generations","s_selection","N_sampled_alleles"],"allowed_forward_operators":["allele_frequency_sequencing"]},"hardness_fn":{"type":"epsilon_fn","delta":5,"kappa":2000,"metric":"Ne_estimation_RMSE_log"},"initiator_dataset":[{"name":"primary","weight":1.0,"ipfs_cid":null,"license_hash":null}],"status":"testnet","staked_pwm":0.0,"chain_hash":"0x4032c97662301a11eb728fee50ab6352f9031854e796853bc3533d2002b8f0c4","chain_tx_hash":"0xa78c1cdf96ae810ee096d0a93e8f4d4ee0ea9c94742642b5f2e428fe3ba97876","chain_block":41555219}