{"artifact_id":"L1-404","layer":"L1","title":"Pharmacodynamics Dose-Response Inversion","domain":"Computational Biology","sub_domain":"Pharmacodynamics","physics_fingerprint":{"L_DAG":2.0,"title":"Pharmacodynamics Dose-Response Inversion","domain":"Computational Biology","carrier":"N/A","primitives":["N.pointwise","O.nls.pd_fit","S.bayesian.pd_posterior"],"sub_domain":"Pharmacodynamics","noise_model":"lognormal","problem_class":"parameter_estimation","solution_space":"PD_parameter_vector","difficulty_delta":3,"integration_axis":"concentration_space","sensing_mechanism":"effect_concentration_measurement"},"observable_profile":{"metric":"EC50_RMSE_fold","regime":"Existence of the recovered PD_parameter_vector is guaranteed within the declared Omega bounds. Uniqueness holds on the measurement-supported subspace; out-of-support modes are controlled by declared priors. Stability is conditionally stable (kappa_eff ~= 20); inter_individual_variability_PD dominates the stability cliff; the remaining mismatch parameters contribute higher-order bias terms. Lognormal sets the irreducible data-fidelity floor.","secondary":"dose_response_fit_RMSE"},"size_tiers":{"center_spec":{"omega":{"n_Hill":1.5,"EC50_nM":100,"N_dose_groups":6,"noise_CV_percent":20},"input_format":"measurement_only","problem_class":"parameter_estimation","forward_operator":"effect_concentration_measurement","epsilon_fn_center":"1.5 EC50_RMSE_fold"},"omega_bounds":{"n_Hill":[0.5,5.0],"EC50_nM":[0.1,1000000.0],"N_dose_groups":[3,20],"noise_CV_percent":[5,100]},"epsilon_bounds":{"EC50_RMSE_fold":[1.05,5.0]},"allowed_problem_classes":["parameter_estimation"],"allowed_omega_dimensions":["N_dose_groups","EC50_nM","n_Hill","noise_CV_percent"],"allowed_forward_operators":["effect_concentration_measurement"]},"hardness_fn":{"type":"epsilon_fn","delta":3,"kappa":500,"metric":"EC50_RMSE_fold"},"initiator_dataset":[{"name":"primary","weight":1.0,"ipfs_cid":null,"license_hash":null}],"status":"testnet","staked_pwm":0.0,"chain_hash":"0xee72c89da66e97ecd73154e158d753de9735dce17b199c8d1c2705bf9f7b2306","chain_tx_hash":"0xf1404d5483048628ad972f47ef4f4a0777d7ae50c5149a0db8d6a701d545f40d","chain_block":41555218}