{"artifact_id":"L1-403","layer":"L1","title":"Physiologically Based PK (PBPK)","domain":"Computational Biology","sub_domain":"Systems pharmacology","physics_fingerprint":{"L_DAG":4.0,"title":"Physiologically Based PK (PBPK)","domain":"Computational Biology","carrier":"N/A","primitives":["D.time","S.qsr.tissue_binding","O.nlme.pbpk_fit"],"sub_domain":"Systems pharmacology","noise_model":"lognormal","problem_class":"parameter_estimation","solution_space":"PBPK_parameter_vector","difficulty_delta":5,"integration_axis":"organ_system","sensing_mechanism":"tissue_concentration_measurement"},"observable_profile":{"metric":"plasma_RMSE_fold_error","regime":"Existence of the recovered PBPK_parameter_vector is guaranteed within the declared Omega bounds. Uniqueness holds on the measurement-supported subspace; out-of-support modes are controlled by declared priors. Stability is conditionally stable (kappa_eff ~= 500); in_vitro_in_vivo_extrapolation_IVIVE_bias dominates the stability cliff; the remaining mismatch parameters contribute higher-order bias terms. Lognormal sets the irreducible data-fidelity floor.","secondary":"tissue_Kp_RMSE_log"},"size_tiers":{"center_spec":{"omega":{"CL_int_L_hr":20,"species_BW_kg":70,"N_organs_modeled":15,"fu_fraction_unbound":0.1},"input_format":"measurement_only","problem_class":"parameter_estimation","forward_operator":"tissue_concentration_measurement","epsilon_fn_center":"2 plasma_RMSE_fold_error"},"omega_bounds":{"CL_int_L_hr":[0.1,1000],"species_BW_kg":[0.02,500],"N_organs_modeled":[5,25],"fu_fraction_unbound":[0.001,1.0]},"epsilon_bounds":{"plasma_RMSE_fold_error":[1.0,10.0]},"allowed_problem_classes":["parameter_estimation"],"allowed_omega_dimensions":["N_organs_modeled","CL_int_L_hr","fu_fraction_unbound","species_BW_kg"],"allowed_forward_operators":["tissue_concentration_measurement"]},"hardness_fn":{"type":"epsilon_fn","delta":5,"kappa":10000.0,"metric":"plasma_RMSE_fold_error"},"initiator_dataset":[{"name":"primary","weight":1.0,"ipfs_cid":null,"license_hash":null}],"status":"testnet","staked_pwm":0.0,"chain_hash":"0x01a1cd45de8d4c7fffff836b170d1e55dc5e0d7886115b617875f91fae49aa8b","chain_tx_hash":"0x3413d775b5969bb353b1f6a4ebc170167950d11d98a7eac9217ed5de6acf3831","chain_block":41555218}