{"artifact_id":"L1-396","layer":"L1","title":"Hodgkin-Huxley Neuron Model Parameter Estimation","domain":"Computational Biology","sub_domain":"Computational neuroscience","physics_fingerprint":{"L_DAG":3.5,"title":"Hodgkin-Huxley Neuron Model Parameter Estimation","domain":"Computational Biology","carrier":"N/A","primitives":["D.time","O.chi2.voltage_trace","S.mcmc.bayesian_parameter"],"sub_domain":"Computational neuroscience","noise_model":"gaussian","problem_class":"parameter_estimation","solution_space":"HH_parameter_vector","difficulty_delta":5,"integration_axis":"time","sensing_mechanism":"patch_clamp_voltage_measurement"},"observable_profile":{"metric":"voltage_trace_RMSE_mV","regime":"Existence of the recovered HH_parameter_vector is guaranteed within the declared Omega bounds. Uniqueness holds on the measurement-supported subspace; out-of-support modes are controlled by declared priors. Stability is conditionally stable (kappa_eff ~= 1000); channel_noise_stochastic dominates the stability cliff; the remaining mismatch parameters contribute higher-order bias terms. Gaussian sets the irreducible data-fidelity floor.","secondary":"spike_timing_error_ms"},"size_tiers":{"center_spec":{"omega":{"g_Na_ratio":120,"I_ext_uA_cm2":10,"temperature_C":6.3,"N_voltage_samples":10000},"input_format":"measurement_only","problem_class":"parameter_estimation","forward_operator":"patch_clamp_voltage_measurement","epsilon_fn_center":"2.0 voltage_trace_RMSE_mV"},"omega_bounds":{"g_Na_ratio":[50,500],"I_ext_uA_cm2":[0,50],"temperature_C":[0,37],"N_voltage_samples":[1000,100000]},"epsilon_bounds":{"voltage_trace_RMSE_mV":[0.2,20.0]},"allowed_problem_classes":["parameter_estimation"],"allowed_omega_dimensions":["g_Na_ratio","temperature_C","I_ext_uA_cm2","N_voltage_samples"],"allowed_forward_operators":["patch_clamp_voltage_measurement"]},"hardness_fn":{"type":"epsilon_fn","delta":5,"kappa":50000.0,"metric":"voltage_trace_RMSE_mV"},"initiator_dataset":[{"name":"primary","weight":1.0,"ipfs_cid":null,"license_hash":null}],"status":"testnet","staked_pwm":0.0,"chain_hash":"0x0074d8715b7c2c36083cafb128edee3a0f95e23f753fe1bdd627106c1bebb2c3","chain_tx_hash":"0xf8caebe1341877f30445bda4241cd04ad18b051ea44cf87f060b15574f17369b","chain_block":41555199}