{"artifact_id":"L1-161","layer":"L1","title":"Correlative Light-Electron Microscopy (CLEM)","domain":"Multimodal Fusion","sub_domain":"Fluorescence + TEM/SEM on the same sample","physics_fingerprint":{"L_DAG":4.0,"title":"Correlative Light-Electron Microscopy (CLEM)","domain":"Multimodal Fusion","carrier":"electron","primitives":["L.fluorescence_imaging","L.em_imaging","L.multi_scale_registration","int.spatial"],"sub_domain":"Fluorescence + TEM/SEM on the same sample","noise_model":"shot_poisson","problem_class":"nonlinear_inverse","solution_space":"2D_fluorescence_plus_em","difficulty_delta":5,"integration_axis":"spatial","sensing_mechanism":"correlative_light_electron"},"observable_profile":{"metric":"PSNR_dB","regime":"Existence of the recovered 2D fluorescence plus em is guaranteed within the declared Omega bounds. Uniqueness is local rather than global (non-convex landscape); convergence depends on initialisation and priors. Stability is moderately conditioned (kappa_eff ~= 18); scale_mismatch dominates the stability cliff; sample_preparation_artifact and the remaining mismatch parameters contribute higher-order bias terms. Photon-shot-noise-limited (poisson counting) sets the irreducible data-fidelity floor, while TV / wavelet-sparsity / deep priors stabilise recovery at the ill-conditioned end of Omega.","secondary":"SSIM"},"size_tiers":{"center_spec":{"omega":{"H_em":4096,"H_lm":2048,"W_em":4096,"W_lm":2048,"pixel_em_nm":2,"pixel_lm_nm":100,"scale_mismatch":0.0,"registration_error":0.0,"photobleaching_pre_em":0.0,"sample_preparation_artifact":0.0},"input_format":"measurement_only","problem_class":"clem","forward_operator":"clem_forward","epsilon_fn_center":"22.0"},"omega_bounds":{"H_em":[1024,16384],"H_lm":[512,8192],"W_em":[1024,16384],"W_lm":[512,8192],"pixel_em_nm":[0.5,10],"scale_mismatch":[0.0,0.5],"registration_error":[0.0,50],"photobleaching_pre_em":[0.0,0.8],"sample_preparation_artifact":[0.0,0.5]},"epsilon_bounds":{"psnr_db":[5.0,40.0]},"allowed_problem_classes":["clem"],"allowed_omega_dimensions":["H_lm","W_lm","H_em","W_em","pixel_lm_nm","pixel_em_nm","scale_mismatch","sample_preparation_artifact","registration_error","photobleaching_pre_em","scale_mismatch","sample_preparation_artifact","registration_error","photobleaching_pre_em"],"allowed_forward_operators":["clem_forward"]},"hardness_fn":{"type":"epsilon_fn","delta":5,"kappa":360,"metric":"PSNR_dB"},"initiator_dataset":[{"name":"primary","weight":1.0,"ipfs_cid":null,"license_hash":null}],"status":"testnet","staked_pwm":0.0,"chain_hash":"0xf35fddbabe325d6ca5fe6c6410ea24ed6f0dbe54917ab9803db29340d14582a6","chain_tx_hash":"0x0cab3a6a54a13fe4871cb9747b0a0f136cc5e75ef8c1c8b0267e631224c32aa5","chain_block":41554242}