{"artifact_id":"L1-092","layer":"L1","title":"Cryo-Electron Tomography (cryoET) — in-situ 3D biology at nm scale","domain":"Electron Microscopy","sub_domain":"In-situ structural biology via cryo tilt-series","physics_fingerprint":{"L_DAG":4.5,"title":"Cryo-Electron Tomography (cryoET) — in-situ 3D biology at nm scale","domain":"Electron Microscopy","carrier":"electron","primitives":["L.transmit_sample","S.scan.angular","L.backproject","L.subtomogram_average","int.angular"],"sub_domain":"In-situ structural biology via cryo tilt-series","noise_model":"shot_poisson","problem_class":"linear_inverse","solution_space":"3D_density","difficulty_delta":10,"integration_axis":"angular","sensing_mechanism":"cryo_electron_transmission"},"observable_profile":{"metric":"PSNR_dB","regime":"Existence of the recovered 3D density is guaranteed within the declared Omega bounds. Uniqueness holds on the measurement-supported subspace; out-of-support modes are controlled by the declared priors. Stability is moderately conditioned (kappa_eff ~= 35); tilt_angle_error dominates the stability cliff; CTF_per_tilt and the remaining mismatch parameters contribute higher-order bias terms. Photon-shot-noise-limited (poisson counting) sets the irreducible data-fidelity floor, while TV / wavelet-sparsity / deep priors stabilise recovery at the ill-conditioned end of Omega.","secondary":"SSIM"},"size_tiers":{"center_spec":{"omega":{"H":4096,"W":4096,"Z":256,"kV":300,"N_tilts":61,"beam_damage":0.2,"total_dose_e":60,"missing_wedge":0.33,"tilt_range_deg":60,"tilt_angle_error":0.0},"input_format":"measurement_only","problem_class":"cryoet_tilt_series","forward_operator":"cryoet_tilt_series_forward","epsilon_fn_center":"22.0"},"omega_bounds":{"H":[1024,8192],"W":[1024,8192],"Z":[64,1024],"kV":[300,300],"N_tilts":[20,200],"beam_damage":[0.0,0.8],"total_dose_e":[20,200],"missing_wedge":[0.1,0.5],"dose_weighting":[0.0,1.0],"tilt_range_deg":[40,80],"tilt_angle_error":[0.0,0.3]},"epsilon_bounds":{"psnr_db":[10.0,40.0]},"allowed_problem_classes":["cryoet_tilt_series"],"allowed_omega_dimensions":["H","W","Z","N_tilts","tilt_range_deg","kV","total_dose_e","tilt_angle_error","missing_wedge","beam_damage","tilt_angle_error","CTF_per_tilt","beam_damage","missing_wedge","dose_weighting"],"allowed_forward_operators":["cryoet_tilt_series_forward"]},"hardness_fn":{"type":"epsilon_fn","delta":10,"kappa":700,"metric":"PSNR_dB"},"initiator_dataset":[{"name":"primary","weight":1.0,"ipfs_cid":null,"license_hash":null}],"status":"testnet","staked_pwm":0.0,"chain_hash":"0x0dbf3b1a3249338f26ada5f995e0eff81af86c94902cebc8b873a412a75666d1","chain_tx_hash":"0x2b24a247c36da2878087519cc99e669d3cb0cc60ad41af578be47e17fbc2f306","chain_block":41554185}