{"artifact_id":"L1-064","layer":"L1","title":"Confocal Laser Endomicroscopy (CLE)","domain":"Medical Imaging","sub_domain":"In-vivo cellular-resolution fluorescence imaging","physics_fingerprint":{"L_DAG":3.3,"title":"Confocal Laser Endomicroscopy (CLE)","domain":"Medical Imaging","carrier":"photon","primitives":["L.laser_excitation","K.psf.confocal","S.scan.raster","int.temporal"],"sub_domain":"In-vivo cellular-resolution fluorescence imaging","noise_model":"poisson_gaussian","problem_class":"linear_inverse","solution_space":"2D_intensity","difficulty_delta":3,"integration_axis":"temporal","sensing_mechanism":"confocal_laser_scan"},"observable_profile":{"metric":"PSNR_dB","regime":"Existence of the recovered 2D intensity is guaranteed within the declared Omega bounds. Uniqueness holds on the measurement-supported subspace; out-of-support modes are controlled by the declared priors. Stability is moderately conditioned (kappa_eff ~= 12); motion dominates the stability cliff; photobleaching and the remaining mismatch parameters contribute higher-order bias terms. Poisson signal noise + gaussian read noise sets the irreducible data-fidelity floor, while mild Tikhonov or analytic inversion is sufficient at the nominal Omega point.","secondary":"SSIM"},"size_tiers":{"center_spec":{"omega":{"H":1024,"W":1024,"NA":0.7,"f_MHz":1,"motion":0.0,"pixel_um":1.0,"peak_photons":200,"photobleaching":0.0,"tissue_contact_pressure":0.0},"input_format":"measurement_only","problem_class":"cle","forward_operator":"cle_forward","epsilon_fn_center":"26.0"},"omega_bounds":{"H":256,"W":256,"NA":[0.5,1.2],"f_MHz":[0.1,10],"motion":[0.0,0.5],"pixel_um":[0.5,5.0],"peak_photons":[20,2000],"photobleaching":[0.0,0.5],"tissue_contact_pressure":[0.0,0.3],"fluorophore_uptake_variation":[0.0,0.3]},"epsilon_bounds":{"psnr_db":[5.0,45.0]},"allowed_problem_classes":["cle"],"allowed_omega_dimensions":["H","W","pixel_um","NA","peak_photons","f_MHz","motion","photobleaching","tissue_contact_pressure","motion","photobleaching","tissue_contact_pressure","fluorophore_uptake_variation"],"allowed_forward_operators":["cle_forward"]},"hardness_fn":{"type":"epsilon_fn","delta":3,"kappa":240,"metric":"PSNR_dB"},"initiator_dataset":[{"name":"primary","weight":1.0,"ipfs_cid":null,"license_hash":null}],"status":"testnet","staked_pwm":0.0,"chain_hash":"0x0e0a0d65f735fb52bdc06164bbae7d769eeac2658404a7e3cd11d120050a7c35","chain_tx_hash":"0x59bee09aaacfa7c75be20e09c22d6fb3eba3678801d2e3add0d14deae59aaef6","chain_block":41553386}