{"artifact_id":"L1-024","layer":"L1","title":"DNA-PAINT (transient DNA-hybridization localization microscopy)","domain":"Microscopy","sub_domain":"Programmable-blinking single-molecule super-resolution","physics_fingerprint":{"L_DAG":4.0,"title":"DNA-PAINT (transient DNA-hybridization localization microscopy)","domain":"Microscopy","carrier":"photon","primitives":["L.dna_hybridization_blinking","K.psf.airy","L.gaussian_fit","int.temporal"],"sub_domain":"Programmable-blinking single-molecule super-resolution","noise_model":"shot_poisson","problem_class":"nonlinear_inverse","solution_space":"point_list","difficulty_delta":10,"integration_axis":"temporal","sensing_mechanism":"single_molecule_localization"},"observable_profile":{"metric":"localization_precision_nm","regime":"Existence of the recovered point list is guaranteed within the declared Omega bounds. Uniqueness is local rather than global (non-convex landscape); convergence depends on initialisation and priors. Stability is moderately conditioned (kappa_eff ~= 28); docking_strand_concentration dominates the stability cliff; drift_nm_per_frame and the remaining mismatch parameters contribute higher-order bias terms. Photon-shot-noise-limited (poisson counting) sets the irreducible data-fidelity floor, while TV / wavelet-sparsity / deep priors stabilise recovery at the ill-conditioned end of Omega.","secondary":"detection_recall"},"size_tiers":{"center_spec":{"omega":{"H":256,"W":256,"NA":1.49,"T_frames":30000,"pixel_nm":160,"drift_nm_per_frame":0.0,"photons_per_binding":5000,"non_specific_binding":0.02,"strand_concentration_nM":5},"input_format":"measurement_only","problem_class":"dnapaint","forward_operator":"dnapaint_forward","epsilon_fn_center":"8.0"},"omega_bounds":{"H":[64,2048],"W":[64,2048],"NA":[1.3,1.49],"T_frames":[5000,200000],"pixel_nm":[80,300],"drift_nm_per_frame":[0.0,3.0],"photons_per_binding":[500,50000],"non_specific_binding":[0.0,0.2],"strand_concentration_nM":[0.5,50]},"epsilon_bounds":{"localization_nm":[0.5,50.0]},"allowed_problem_classes":["dnapaint"],"allowed_omega_dimensions":["H","W","T_frames","pixel_nm","NA","photons_per_binding","strand_concentration_nM","drift_nm_per_frame","non_specific_binding","docking_strand_concentration","drift_nm_per_frame","non_specific_binding"],"allowed_forward_operators":["dnapaint_forward"]},"hardness_fn":{"type":"epsilon_fn","delta":10,"kappa":560,"metric":"localization_precision_nm"},"initiator_dataset":[{"name":"primary","weight":1.0,"ipfs_cid":null,"license_hash":null}],"status":"testnet","staked_pwm":0.0,"chain_hash":"0x4edb8ecb50a6b1edb2f3b4f786698438c74036348e3bd3f3737100858e1b4fa6","chain_tx_hash":"0xc1190d7b1d1a36d54875331e7c64136ada552c562d976632d12d21f58d60c84e","chain_block":41554169}