{"artifact_id":"L1-014","layer":"L1","title":"Expansion Microscopy (ExM) — physical hydrogel expansion","domain":"Microscopy","sub_domain":"Sample-side super-resolution via isotropic swelling","physics_fingerprint":{"L_DAG":2.5,"title":"Expansion Microscopy (ExM) — physical hydrogel expansion","domain":"Microscopy","carrier":"photon","primitives":["L.sample_expansion","K.psf.airy","int.temporal"],"sub_domain":"Sample-side super-resolution via isotropic swelling","noise_model":"poisson_gaussian","problem_class":"linear_inverse","solution_space":"2D_intensity","difficulty_delta":3,"integration_axis":"temporal","sensing_mechanism":"fluorescence_widefield"},"observable_profile":{"metric":"PSNR_dB","regime":"Existence of the recovered 2D intensity is guaranteed within the declared Omega bounds. Uniqueness holds on the measurement-supported subspace; out-of-support modes are controlled by the declared priors. Stability is well-conditioned (kappa_eff ~= 9); expansion_anisotropy dominates the stability cliff; expansion_factor_drift and the remaining mismatch parameters contribute higher-order bias terms. Poisson signal noise + gaussian read noise sets the irreducible data-fidelity floor, while mild Tikhonov or analytic inversion is sufficient at the nominal Omega point.","secondary":"SSIM"},"size_tiers":{"center_spec":{"omega":{"H":1024,"W":1024,"NA":1.4,"F_expand":4.0,"pixel_nm":65,"peak_photons":500,"expansion_anisotropy":0.01,"expansion_factor_drift":0.01},"input_format":"measurement_only","problem_class":"exm","forward_operator":"exm_forward","epsilon_fn_center":"29.0"},"omega_bounds":{"H":[256,4096],"W":[256,4096],"NA":[1.0,1.49],"F_expand":[2.0,20.0],"pixel_nm":[30,200],"peak_photons":[50,5000],"labeling_loss":[0.0,0.3],"expansion_anisotropy":[0.0,0.1],"expansion_factor_drift":[0.0,0.1]},"epsilon_bounds":{"psnr_db":[12.0,42.0]},"allowed_problem_classes":["exm"],"allowed_omega_dimensions":["H","W","pixel_nm","NA","F_expand","peak_photons","expansion_anisotropy","expansion_factor_drift","expansion_anisotropy","expansion_factor_drift","labeling_loss"],"allowed_forward_operators":["exm_forward"]},"hardness_fn":{"type":"epsilon_fn","delta":3,"kappa":180,"metric":"PSNR_dB"},"initiator_dataset":[{"name":"primary","weight":1.0,"ipfs_cid":null,"license_hash":null}],"status":"testnet","staked_pwm":0.0,"chain_hash":"0x58199cb8a72dcc774e6eb7374523c69ff971193ff50bef3f32a33ecc70dd08ec","chain_tx_hash":"0xb92916a6b1edab33ba8493d43604696f92b49a5ce5efd0b938503ff0532b707d","chain_block":41554155}