{"artifact_id":"L1-011","layer":"L1","title":"PALM / STORM (single-molecule localization microscopy)","domain":"Microscopy","sub_domain":"Single-molecule localization super-resolution","physics_fingerprint":{"L_DAG":4.2,"title":"PALM / STORM (single-molecule localization microscopy)","domain":"Microscopy","carrier":"photon","primitives":["K.psf.airy","D.threshold.isolated","L.gaussian_fit","int.temporal"],"sub_domain":"Single-molecule localization super-resolution","noise_model":"shot_poisson","problem_class":"nonlinear_inverse","solution_space":"point_list","difficulty_delta":10,"integration_axis":"temporal","sensing_mechanism":"single_molecule_localization"},"observable_profile":{"metric":"localization_precision_nm","regime":"Existence of the recovered point list is guaranteed within the declared Omega bounds. Uniqueness is local rather than global (non-convex landscape); convergence depends on initialisation and priors. Stability is moderately conditioned (kappa_eff ~= 30); drift_nm_per_frame dominates the stability cliff; multi_emitter_overlap and the remaining mismatch parameters contribute higher-order bias terms. Photon-shot-noise-limited (poisson counting) sets the irreducible data-fidelity floor, while TV / wavelet-sparsity / deep priors stabilise recovery at the ill-conditioned end of Omega.","secondary":"detection_recall"},"size_tiers":{"center_spec":{"omega":{"H":256,"W":256,"NA":1.49,"T_frames":10000,"pixel_nm":160,"background_bias":50,"drift_nm_per_frame":0.0,"N_emitters_per_frame":50,"photons_per_molecule":3000},"input_format":"measurement_only","problem_class":"smlm","forward_operator":"smlm_forward","epsilon_fn_center":"15.0"},"omega_bounds":{"H":[64,2048],"W":[64,2048],"NA":[1.3,1.49],"T_frames":[1000,100000],"pixel_nm":[80,300],"background_bias":[10,500],"blinking_kinetics":[0.0,0.2],"drift_nm_per_frame":[0.0,5.0],"N_emitters_per_frame":[5,500],"photons_per_molecule":[500,20000],"multi_emitter_overlap":[0.0,0.5]},"epsilon_bounds":{"localization_nm":[0.5,50.0]},"allowed_problem_classes":["smlm"],"allowed_omega_dimensions":["H","W","T_frames","pixel_nm","NA","photons_per_molecule","N_emitters_per_frame","drift_nm_per_frame","background_bias","drift_nm_per_frame","multi_emitter_overlap","background_bias","blinking_kinetics"],"allowed_forward_operators":["smlm_forward"]},"hardness_fn":{"type":"epsilon_fn","delta":10,"kappa":600,"metric":"localization_precision_nm"},"initiator_dataset":[{"name":"primary","weight":1.0,"ipfs_cid":null,"license_hash":null}],"status":"testnet","staked_pwm":0.0,"chain_hash":"0x9500e1c2916952fa19efc571aa507dfa579922aece34a60e32b8d25664d5fe42","chain_tx_hash":"0xf0725c4e2ead287799c36b1cd3c3aefef5bd5ba4a27a561860b90e8fa4db446e","chain_block":41554155}