{"artifact_id":"L1-007","layer":"L1","title":"Fluorescence Lifetime Imaging Microscopy (FLIM)","domain":"Microscopy","sub_domain":"Time-correlated single photon counting","physics_fingerprint":{"L_DAG":3.0,"title":"Fluorescence Lifetime Imaging Microscopy (FLIM)","domain":"Microscopy","carrier":"photon","primitives":["L.excitation.pulsed","D.tcspc_histogram","int.temporal"],"sub_domain":"Time-correlated single photon counting","noise_model":"shot_poisson","problem_class":"nonlinear_inverse","solution_space":"2D_lifetime","difficulty_delta":3,"integration_axis":"temporal","sensing_mechanism":"tcspc_lifetime"},"observable_profile":{"metric":"PSNR_dB","regime":"Existence of the recovered 2D lifetime is guaranteed within the declared Omega bounds. Uniqueness is local rather than global (non-convex landscape); convergence depends on initialisation and priors. Stability is moderately conditioned (kappa_eff ~= 12); IRF_shape_drift dominates the stability cliff; afterpulsing_rate and the remaining mismatch parameters contribute higher-order bias terms. Photon-shot-noise-limited (poisson counting) sets the irreducible data-fidelity floor, while mild Tikhonov or analytic inversion is sufficient at the nominal Omega point.","secondary":"SSIM"},"size_tiers":{"center_spec":{"omega":{"H":256,"W":256,"N_t":256,"N_tau":1,"photon_count":500,"tau_range_ns":[0.5,8.0],"IRF_shape_drift":0.0,"ambient_fluorescence":0.0},"input_format":"measurement_only","problem_class":"flim_tcspc","forward_operator":"flim_tcspc_forward","epsilon_fn_center":"0.1"},"omega_bounds":{"H":[64,1024],"W":[64,1024],"N_t":[64,1024],"N_tau":[1,3],"photon_count":[20,10000],"IRF_shape_drift":[0.0,0.2],"afterpulsing_rate":[0.0,0.05],"ambient_fluorescence":[0.0,0.2]},"epsilon_bounds":{"psnr_db":[12.0,42.0]},"allowed_problem_classes":["flim_tcspc"],"allowed_omega_dimensions":["H","W","N_t","photon_count","N_tau","tau_range_ns","IRF_shape_drift","ambient_fluorescence","IRF_shape_drift","afterpulsing_rate","ambient_fluorescence"],"allowed_forward_operators":["flim_tcspc_forward"]},"hardness_fn":{"type":"epsilon_fn","delta":3,"kappa":240,"metric":"PSNR_dB"},"initiator_dataset":[{"name":"primary","weight":1.0,"ipfs_cid":null,"license_hash":null}],"status":"testnet","staked_pwm":0.0,"chain_hash":"0x946340703e52739d464cc09d82470a4295ddff89f84d1fc4ed17d58b600a6cba","chain_tx_hash":"0x6de3035aa50fca6421f6d8bd3eb46a1e6a4abfc80bb1b54be566893ed7faaa3c","chain_block":41554154}